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Catalog Number Size Price
LS-H6455-5 5 mg $75 
LS-H6455-10 10 mg $145 
LS-H6455-50 50 mg $515 
LS-H6455-100 100 mg $880 
Agomelatine Biochemical - Agomelatine Structure

Agomelatine (CAS 138112-76-2) - LS-H6455

Agomelatine (CAS 138112-76-2) - LS-H6455

Available for shipment within the USA only
Description:
Melatonin, produced in the pineal gland, is an endogenous regulator of circadian rhythms. It acts through the melatonin receptors (MT1 and MT2) and has been shown to have anti-depressant activity in experimental models of clinical depression. Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. However, unlike melatonin, agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C ) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo . It also dose-dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats.
Price
Catalog Number
$75 
LS-H6455-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Melatonin, produced in the pineal gland, is an endogenous regulator of circadian rhythms. It acts through the melatonin receptors (MT1 and MT2) and has been shown to have anti-depressant activity in experimental models of clinical depression. Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. However, unlike melatonin, agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C ) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo . It also dose-dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats.

Specifications

CAS Number
138112-76-2
Biological Function
A melatonin receptor agonist and 5-HT antagonist.
Purity
Greater than 98%
Formal Name
N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide
Type
Agomelatine, Valdoxan®
Classification
Biochemical, Chemical
Molecular Formula
C15H17NO2
Molecular Weight
243.3 g/mol
Formulation
a crystalline solid
SMILES
COc1ccc2cccc(CCNC(=O)C)c2c1
InChI Code
InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
InChI Key
YJYPHIXNFHFHND-UHFFFAOYSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
Agomelatine is supplied as a crystalline solid. A stock solution may be made by dissolving the agomelatine in an organic solvent purged with an inert gas. Agomelatine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of agomelatine in these solvents is approximately 30 mg/ml. Agomelatine is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, agomelatine should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Agomelatine has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Agomelatine Biochemical - Agomelatine Structure
Agomelatine Structure

Agomelatine Biochemical - Agomelatine Structure
Agomelatine Structure

Agomelatine Biochemical - Agomelatine Structure
Agomelatine Structure

Agomelatine Biochemical - Agomelatine Structure
Agomelatine Structure

Requested From: United States
Date Requested: 12/12/2019