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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H14491-5 5 mg $85 
LS-H14491-25 25 mg $310 
AG-879 Biochemical - AG-879 Structure

AG-879 (CAS 148741-30-4) - LS-H14491

AG-879 (CAS 148741-30-4) - LS-H14491

Available for shipment within the USA only
Description:
AG-879 inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 uM). No inhibition of EGF, or PDGF receptor phosphorylation is observed at typical working concentrations. MP = 223-224°C
Price
Catalog Number
$85 
LS-H14491-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AG-879 inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 uM). No inhibition of EGF, or PDGF receptor phosphorylation is observed at typical working concentrations. MP = 223-224°C

Specifications

CAS Number
148741-30-4
Biological Function
NGFR kinase inhibitor
Purity
Greater than 99% by TLC and NMR
Formal Name
3,5-Di-t-butyl-4-hydroxybenzylidene cyanothioacetamide
Classification
Biochemical, Chemical, Inhibitor
Molecular Formula
C18H24N2OS
Molecular Weight
316.47
Formulation
Yellow solid
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage
Store at -20°C. After dissolving store at -20°C for up to 3 months.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

AG-879 Biochemical - AG-879 Structure
AG-879 Structure

AG-879 Biochemical - AG-879 Structure
AG-879 Structure

AG-879 Biochemical - AG-879 Structure
AG-879 Structure

AG-879 Biochemical - AG-879 Structure
AG-879 Structure

Requested From: United States
Date Requested: 12/11/2019