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Catalog Number Size Price
LS-H5414-1 1 mg $60 
LS-H5414-5 5 mg $150 
LS-H5414-10 10 mg $250 
Biochemical - Ac-DEVD-AMC Structure

Ac-DEVD-AMC (CAS 169332-61-0) - LS-H5414

Ac-DEVD-AMC (CAS 169332-61-0) - LS-H5414

Description:
Ac-DEVD-AMC is a fluorogenic substrate that can be cleaved specifically by caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
Price
Catalog Number
$60 
LS-H5414-1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
Ac-DEVD-AMC is a fluorogenic substrate that can be cleaved specifically by caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.

Specifications

Conjugations
Unconjugated
CAS Number
169332-61-0
Biological Function
A caspase-3 fluorogenic substrate.
Purity
Greater than 95%
Formal Name
N-acetyl-L-a-aspartyl-L-a-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-a-asparagine
Type
Ac-DEVD-AMC, Caspase-3 Substrate (Fluorogenic), N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin
Classification
Biochemical, Synthetic Peptide
Molecular Formula
C30H37N5O13
Molecular Weight
675.6 g/mol
Formulation
a solution in DMSO
SMILES
CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CCC(O)=O)=O)C(C)C)=O)CC(O)=O)=O)=CC2=O
InChI Code
InChI=1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(
InChI Key
ALZSTTDFHZHSCA-RNVDEAKXSA-N
Sequence
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin
Storage
Store at -20°C for up to 1 year.
Documents
Usage Information
Ac-DEVD-AMC is supplied as a solution in DMSO. The solubility of Ac-DEVD-AMC in DMSO is approximately 10 mg/ml.
Restrictions
For research use only.
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Biochemical - Ac-DEVD-AMC Structure
Ac-DEVD-AMC Structure

Biochemical - Ac-DEVD-AMC Structure
Ac-DEVD-AMC Structure

Biochemical - Ac-DEVD-AMC Structure
Ac-DEVD-AMC Structure

Biochemical - Ac-DEVD-AMC Structure
Ac-DEVD-AMC Structure

Requested From: United States
Date Requested: 2/28/2020