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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-H14581-5 5 mg $110 
LS-H14581-25 25 mg $385 
ABT-418 HCl Biochemical - ABT-418 HCl Structure

ABT-418 HCl (CAS 147388-83-8) - LS-H14581

ABT-418 HCl (CAS 147388-83-8) - LS-H14581

Available for shipment within the USA only
Description:
Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at a4b2 and a2b2 subtypes (EC50= approximately 6 and 11 uM, respectively). Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam. Reduces distractibility in a primate model and may have relevance in attention deficit hyperactivity disorder. Improves cognition in Alzheimer's disease patients.
Price
Catalog Number
$110 
LS-H14581-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at a4b2 and a2b2 subtypes (EC50= approximately 6 and 11 uM, respectively). Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam. Reduces distractibility in a primate model and may have relevance in attention deficit hyperactivity disorder. Improves cognition in Alzheimer's disease patients.

Specifications

CAS Number
147388-83-8
Biological Function
Nicotinic acetylcholine receptor agonist; cognition enhancer
Purity
Greater than 98% by NMR, TLC
Formal Name
3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole hydrochloride
Classification
Biochemical, Chemical, Agonist
Molecular Formula
C9H14N2O HCl
Molecular Weight
202.68
Formulation
Tan solid
Solubility
Soluble in Water (up to 15 mg/ml)
Storage
Store desiccated at -20°C. After dissolving store at -20°C for up to 3 months.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

ABT-418 HCl Biochemical - ABT-418 HCl Structure
ABT-418 HCl Structure

ABT-418 HCl Biochemical - ABT-418 HCl Structure
ABT-418 HCl Structure

ABT-418 HCl Biochemical - ABT-418 HCl Structure
ABT-418 HCl Structure

ABT-418 HCl Biochemical - ABT-418 HCl Structure
ABT-418 HCl Structure

Requested From: United States
Date Requested: 12/11/2019