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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-H14579-5 5 mg $130 
LS-H14579-25 25 mg $465 
AAL-993 Biochemical - AAL-993 Structure

AAL-993 (CAS 269390-77-4) - LS-H14579

AAL-993 (CAS 269390-77-4) - LS-H14579

Available for shipment within the USA only
Description:
AAL-993 inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-b, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
Price
Catalog Number
$130 
LS-H14579-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AAL-993 inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-b, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.

Specifications

CAS Number
269390-77-4
Biological Function
VEGFR inhibitor
Purity
Greater than 98% by NMR, TLC
Formal Name
2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
Classification
Biochemical, Chemical, Inhibitor
Molecular Formula
C20H16F3N3O
Molecular Weight
371.36
Formulation
Pale yellow solid
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage
Store at room temperature. After dissolving store at -20°C for up to 3 months.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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AAL-993 Biochemical - AAL-993 Structure
AAL-993 Structure

AAL-993 Biochemical - AAL-993 Structure
AAL-993 Structure

AAL-993 Biochemical - AAL-993 Structure
AAL-993 Structure

AAL-993 Biochemical - AAL-993 Structure
AAL-993 Structure

Requested From: United States
Date Requested: 12/8/2019