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Catalog Number Size Price
LS-H14577-5 5 mg $90 
LS-H14577-25 25 mg $315 
A-769662 Biochemical - A-769662 Structure

A-769662 (CAS 844499-71-4) - LS-H14577

A-769662 (CAS 844499-71-4) - LS-H14577

Available for shipment within the USA only
Description:
A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM. A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. A-769662 synergizes with AICAR. Cell permeable.
Price
Catalog Number
$90 
LS-H14577-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM. A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice. Inhibits adipocyte differentiation. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming. A-769662 synergizes with AICAR. Cell permeable.

Specifications

CAS Number
844499-71-4
Biological Function
AMPK activator
Purity
Greater than 98% (NMR, HPLC)
Formal Name
4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Classification
Biochemical, Chemical, Kinase
Molecular Formula
C20H12N2O3S
Molecular Weight
360.39
Formulation
Beige solid
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
Storage
Store desiccated at -20°C. After dissolving store at -20°C for up to 3 months.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

A-769662 Biochemical - A-769662 Structure
A-769662 Structure

A-769662 Biochemical - A-769662 Structure
A-769662 Structure

A-769662 Biochemical - A-769662 Structure
A-769662 Structure

A-769662 Biochemical - A-769662 Structure
A-769662 Structure

Requested From: United States
Date Requested: 12/15/2019