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VEGFR2 Kinase Inhibitor I (CAS 15966-93-5) LS-H92

VEGFR2 inhibitor, KDR inhibitor, FLK1 inhibitor
LS-H92-500 / 500 µg / $195
LS-H92-1000 / 1000 µg / $225
LS-H92-5000 / 5000 µg / $465
LS-H92-10000 / 10000 µg / $800
USA Shipment Only
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Description: Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM). It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM). H92_ChemicalStructureImage.png
5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, ethyl ester
SU5408
biochemical, chemical, inhibitor
LS-H92
15966-93-5
C18H18N2O3
≥95%
A crystalline solid
 
O=C(N1)/C(C2=C1C=CC=C2)=C\C3=C(C)C(C(OCC)=O)=C(C)N3
InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
PMUJUSJUVIXDQC-LCYFTJDESA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: KDR / VEGFR2 / FLK1 related products

Usage Information

VEGFR2 kinase inhibitor I is supplied as a crystalline solid. A stock solution may be made by dissolving the VEGFR2 kinase inhibitor I in the solvent of choice. VEGFR2 kinase inhibitor I is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of VEGFR2 kinase inhibitor I in these solvents is approximately 1 mg/ml. VEGFR2 kinase inhibitor I is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Sun, L., Tran, N., Tang, F., et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J. Med. Chem. 41(14), 2588-2603 (1998).

 


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