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UDP-Glucose (sodium salt) (CAS 28053-08-9) LS-H119

P2Y14 receptor ligand, GPR17 ligand
LS-H119-100 / 100 mg / $195
LS-H119-1000 / 1000 mg / $295
USA Shipment Only
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Description: UDP-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14 receptor (EC50 = 0.35 µM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells. It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 µM. H119_ChemicalStructureImage.png
P'-α-D-glucopyranosyl ester uridine 5'-(trihydrogen diphosphate), disodium salt
UDPG
UDP-Glucose
Uridine-5'-diphosphoglucose
chemical, biochemical, ligand
LS-H119
28053-08-9
C15H22N2O17P2 • 2Na
≥98%
A crystalline solid
 
O[C@@H]1[C@@H](COP(OP(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)([O-])=O)([O-])=O)O[C@@H](N3C=CC(NC3=O)=O)[C@@H]1O.[Na+].[Na+]
InChI=1S/C15H24N2O17P2.2Na/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;/q;2*+1/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;/m1../
PKJQEQVCYGYYMM-QBNUFUENSA-L
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: P2RY14 / GPR105 GPR17 related products

Usage Information

UDP-α-D-Glucose (UDPG) (sodium salt) is supplied as a crystalline solid. Aqueous solutions of (UDPG) (sodium salt) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of (UDPG) (sodium salt) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
  2. Lecca, D., Trincavelli, M.L., Gelosa, P., et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 3(10), (2008).

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