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Sulprostone (CAS 60325-46-4) LS-H106

EP3 receptor agonist
LS-H106-500 / 500 µg / $195
LS-H106-1000 / 1000 µg / $225
LS-H106-5000 / 5000 µg / $415
LS-H106-10000 / 10000 µg / $665
USA Shipment Only
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Description: Sulprostone is a metabolism resistant synthetic analog of PGE2. It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 µM for the inhibition of PGE2 binding. Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity. H106_ChemicalStructureImage.png
N-(methylsulfonyl)-9-oxo-11α,15R-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-amide
 
biochemical, chemical, agonist
LS-H106
60325-46-4
C23H31NO7S
≥98%
A solution in methyl acetate
 
O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1
InChI=1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,22-/m1/s1
UQZVCDCIMBLVNR-TWYODKAFSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PTGER3 / EP3 related products

Usage Information

Sulprostone is supplied as a solution in methyl acetate. To change the solvent, simply evaporate the sulprostone under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as DMSO and dimethyl formamide purged with an inert gas can be used. The solubility of sulprostone in these solvents is approximately 10 mg/ ml. Sulprostone is soluble in ethanol at a concentration of approximately 25 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing any biological experiments. Avoid adding Sulprostoneto basic solutions (pH >7.4), as base treatment will degrade sulprostone to PGA and PGB compounds. Also, ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. If an organic solvent-free solution of sulprostone is needed, it can be prepared by evaporating the methyl acetate and directly dissolving the neat oil in aqueous buffers.The solubility of sulprostone in PBS (pH 7.2) is approximately 4 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Schaaf, T.K., Bindra, J.S., Eggler, J.F., et al. N-(Methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissueselective uterine stimulants. J. Med. Chem. 24, 1353-1359 (1981).

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