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PSN375963 (CAS 388575-52-8) LS-H20

PPAR alpha agonist
LS-H20-1 / 1 mg / $165
LS-H20-5 / 5 mg / $205
LS-H20-10 / 10 mg / $235
LS-H20-25 / 25 mg / $325
USA Shipment Only
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Description: GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl ethanolamide (OEA), an endogenous, potent agonist for PPAR alpha . PSN375963 is a potent and selective agonist of GPR119 that shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 8.4 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively). These data suggest that PSN375963 may be useful as a therapeutic agent for the treatment of obesity. H20_ChemicalStructureImage.png
4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
 
biochemical, chemical, agonist
LS-H20
388575-52-8
C17H23N3O
≥98%
A crystalline solid
 
CCCCC1CCC(CC1)c1onc(n1)c1ccncc1
InChI=1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
OAVLEYPTWABFLF-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PPARA / PPAR Alpha related products

Usage Information

PSN375963 is supplied as a crystalline solid. A stock solution may be made by dissolving the PSN375963 in an organic solvent purged with an inert gas. PSN375963 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of PSN375963 in ethanol and DMF is approximately 30 mg/ml and approximately 5 mg/ml in DMSO. PSN375963 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, PSN375963 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. PSN375963 has a solubility of approximately 0.25 mg/ml in a 1:2 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Fu, J., Gaetani, S., Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93 (2003).
  2. Overton, H.A., Babbs, A.J., Doel, S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metablolism 3, 167-175 (2006).

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