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OXA-01 (CAS 936889-68-8) LS-H157

mTORC1 inhibitor, mTORC2 inhibitor
LS-H157-1 / 1 mg / $175
LS-H157-5 / 5 mg / $235
LS-H157-10 / 10 mg / $295
LS-H157-25 / 25 mg / $465
USA Shipment Only
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Description: OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively). It is selective for mTOR over PI3K isoforms and DNA protein kinase. OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting. H157_ChemicalStructureImage.png
trans-4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid
biochemical, chemical, inhibitor
A crystalline solid
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: CRTC1 / MECT1 / TORC1 CRTC2 / TORC2 related products

Usage Information

OXA-01 is supplied as a crystalline solid. A stock solution may be made by dissolving the OXA-01 in the solvent of choice. OXA-01 is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of OXA-01 in these solvents is approximately 3 and 1 mg/ml, respectively. OXA-01 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, OXA-01 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. OXA-01 has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Falcon, B.L., Barr, S., Gokhale, P.C., et al. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 71(5), 1573-1583 (2011).


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