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ML-179 (CAS 1883548-87-5) LS-H111

LRH-1 agonist
LS-H111-1 / 1 mg / $185
LS-H111-5 / 5 mg / $225
LS-H111-10 / 10 mg / $275
LS-H111-25 / 25 mg / $375
USA Shipment Only
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Description: ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM). H111_ChemicalStructureImage.png
3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione
CID-45100448
biochemical, chemical, agonist
LS-H111
1883548-87-5
C21H25F3N4O2
≥98%
A crystalline solid
 
O=C(N1)N(C2CCCCC2)C(C=C1N(CC3)CCN3C4=CC=CC(C(F)(F)F)=C4)=O
InChI=1S/C21H25F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,25,30)
MFABFKUNLDYKGH-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: NR5A2 / LRH-1 related products

Usage Information

ML-179 is supplied as a crystalline solid. A stock solution may be made by dissolving the ML-179 in the solvent of choice. ML-179 is soluble in DMSO at a concentration of approximately 10 mg/ml. ML-179 is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Busby, S., Nuhant, P., Cameron, M., et al. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2), in Probe Reports from the NIH Molecular Libraries Program, 1 (2010).

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