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LT175 (CAS 862901-87-9) LS-H141

PPAR alpha agonist, PPAR gamma agonist,
LS-H141-1 / 1 mg / $175
LS-H141-5 / 5 mg / $215
LS-H141-10 / 10 mg / $255
LS-H141-25 / 25 mg / $375
USA Shipment Only
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Description: Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPAR alpha demonstrates a particular role in fatty acid oxidation whereas PPAR gamma is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPAR alpha / gamma ligand that displays partial agonism toward PPAR gamma (EC50s = 0.22, 0.26, and 0.48 µM for hPPAR alpha, mPPAR alpha, and hPPAR gamma, respectively). It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice. LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPAR gamma . H141_ChemicalStructureImage.png
αS-([1,1'-biphenyl]-4-yloxy)-benzenepropanoic acid
 
biochemical, chemical, agonist
LS-H141
862901-87-9
C21H18O3
≥98%
A crystalline solid
 
O=C(O)[C@H](CC1=CC=CC=C1)OC(C=C2)=CC=C2C3=CC=CC=C3
InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1
TZTPJJNNACUQQR-FQEVSTJZSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PPARA / PPAR Alpha PPARG / PPAR Gamma related products

Usage Information

LT175 is supplied as a crystalline solid. A stock solution may be made by dissolving the LT175 in the solvent of choice. LT175 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of LT175 in these solvents is approximately 25, 50, and 30 mg/ml, respectively. LT175 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, LT175 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. LT175 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Gilardi, F., Giudici, M., Mitro, N., et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J. Bio. Chem. 289(10), 6908-6920 (2014).

 


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