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Lovastatin Hydroxy Acid (sodium salt) (CAS 75225-50-2) LS-H40

HMG-CoA reductase inhibitor
LS-H40-1 / 1 mg / $185
LS-H40-5 / 5 mg / $215
LS-H40-10 / 10 mg / $235
LS-H40-25 / 25 mg / $335
USA Shipment Only
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Description: Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the `statin' class of cholesterol-lowering drugs. Lovastatin is a HMG-CoA reductase inhibitor that was initially isolated from Aspergillus terreus. Marketed as Mevinolinâ„¢, Mevacorâ„¢, and under several other trade names, lovastatin was the first HMG-CoA reductase inhibitor to be used in the treatment of hypercholesterolemia. It is a competitive inhibitor of HMG-CoA with a Ki value of 0.6 nM for the open ring hydroxy acid form of the molecule. During a three week study in dogs, a dose of 8 mg/kg per day resulted in a 29% reduction in plasma cholesterol. Lovastatin also suppresses TNF-induced NF- kappa B activation (IC50 ~ 15 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. H40_ChemicalStructureImage.png
2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid, monosodium salt
 
biochemical, chemical, inhibitor
LS-H40
75225-50-2
C24H37O6 • Na
≥98%
A crystalline solid
 
C[C@H]1C=CC2=C[C@H](C)C[C@H](OC([C@@H](C)CC)=O)[C@]2([H])[C@H]1CC[C@@H](O)C[C@@H](O)CC([O-])=O.[Na+]
InChI=1S/C24H38O6.Na/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28;/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,18+,19+,20-,21-,23-;/m0./s1
LXZBFUBRYYVRQJ-AXHZAXLDSA-M
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: HMG-CoA Reductase / HMGCR related products

Usage Information

Lovastatin (sodium salt) is supplied as a crystalline solid. A stock solution may be made by dissolving the lovastatin (sodium salt) in an organic solvent purged with an inert gas. Lovastatin (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of lovastatin (sodium salt) in these solvents is approximately 10 mg/ml. If aqueous stock solutions are required for biological experiments, they can best be prepared by diluting the organic solvent into aqueous buffers or isotonic saline. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Tobert, J.A. Nature Reviews Drug Discovery 2, 517-526 (2003).
  2. Endo, A. J. Lipid Res. 33, 1569-1582 (1992).
  3. Alberts, A.W., Chen, J., Kuron, G., et al. Proc. Natl. Acad. Sci. USA 77(7), 3957-3961 (1980).
  4. Ahn, K.S., Sethi, G., and Aggarwal, B.B. Biochem. Pharmacol. 75, 907-913 (2008).

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