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Losartan (potassium salt) (CAS 124750-99-8) LS-H8

AT1 receptor antagonist
LS-H8-10 / 10 mg / $165
LS-H8-50 / 50 mg / $195
LS-H8-100 / 100 mg / $225
LS-H8-500 / 500 mg / $455
USA Shipment Only
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Description: Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is an AT1 receptor antagonist with a Ki value of 5-20 nM. It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats. In humans, losartan controls hypertension while protecting renal function. H8_ChemicalStructureImage.png
2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt
biochemical, chemical, antagonist
C22H23ClN6O • K
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: AGTR1 / AT1 Receptor related products

Usage Information

Losartan (potassium salt) is supplied as a crystalline solid. A stock solution may be made by dissolving the losartan (potassium salt) in an organic solvent purged with an inert gas. Losartan (potassium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of losartan (potassium salt) in these solvents is at least 20 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of losartan (potassium salt) can be prepared by directly dissolving the crystalline compound in aqueous buffers. The solubility of losartan (potassium salt) in PBS (pH 7.2) is at least 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

  1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Hypertension 37(2), 505-511 (2001).
  2. Schiffrin, E.L. Am. J. Hypertens 15, 115S-122S (2002).
  3. Ji, H., Leung, M., Zhang, Y., et al. J. Biol. Chem. 269(24), 16533-16536 (1994).
  4. Ge, J., Huang, D., Liang, C., et al. Atherosclerosis 177, 263-268 (2004).
  5. Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al. Br. J. Pharmacol. 143, 215-225 (2004).


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