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Ki16425 (CAS 355025-24-0) LS-H63

LPA receptor antagonist
LS-H63-1 / 1 mg / $185
LS-H63-5 / 5 mg / $215
LS-H63-10 / 10 mg / $245
LS-H63-100 / 100 mg / $755
USA Shipment Only
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Description: Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 µM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration. H63_ChemicalStructureImage.png
3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid
 
biochemical, chemical, antagonist
LS-H63
355025-24-0
C23H23ClN2O5S
≥95%
A crystalline solid
 
OC(=O)CCSCc1ccc(cc1)c1onc(C)c1NC(=O)OC(C)c1ccccc1Cl
InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)
LLIFMNUXGDHTRO-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: LPA / Lysophosphatidic Acid related products

Usage Information

Ki16425 is supplied as a crystalline solid. A stock solution may be made by dissolving the Ki16425 in an organic solvent purged with an inert gas. Ki16425 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of Ki16425 in these solvents is approximately 10 mg/ml. Ki16425 is sparingly soluble in aqueous buffers. Ki16425 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Ki16425 has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Choi, J.W., Lee, C.-W., and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochim. Biophys. Acta 1781, 531-539 (2008)
  2. Ohta, H., Sato, K., Murata, N., et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol. 64(4), 994-1005 (2003).
  3. Yamada, T., Sato, K., Komachi, M., et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA. J. Biol. Chem. 279(8), 6595-6605 (2004).

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