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GW 9508 (CAS 885101-89-3) LS-H24

GPR40 agonist, GPR120 agonist
LS-H24-5 / 5 mg / $185
LS-H24-10 / 10 mg / $205
LS-H24-50 / 50 mg / $325
LS-H24-100 / 100 mg / $455
USA Shipment Only
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Description: GPR40 (free fatty acid receptor 1; FFAR1) and GPR120 (FFAR4) are G protein-coupled receptors (GPCR) that are activated by medium and long-chain fatty acids. In addition, there is evidence of a link between GPR40 and the ability of fatty acids to acutely potentiate insulin secretion. GW 9508 is a small-molecule agonist of GPR40 and GPR120. Stimulation of intracellular Ca2+ mobilization by GW 9508 in human embryonic kidney (HEK) 293 cells expressing GPR40 and GPR120 was observed with EC50 values of 47 nM and 2.2 µM, respectively. GW 9508 dose dependently potentiates glucose-stimulated insulin secretion and the KCl-mediated increase in insulin secretion in MIN6 cells. H24_ChemicalStructureImage.png
4-[[(3-phenoxyphenyl)methyl]amino]-benzenepropanoic acid
 
biochemical, chemical, agonist
LS-H24
885101-89-3
C22H21NO3
≥98%
A crystalline solid
 
OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1
InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
DGENZVKCTGIDRZ-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FFAR1 / GPR40 related products

Usage Information

GW 9508 is supplied as a crystalline solid. A stock solution may be made by dissolving the GW 9508 in an organic solvent purged with an inert gas. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. The solubility of GW 9508 in these solvents is approximately 15 mg/ml. GW 9508 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GW 9508 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. GW 9508 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br. J. Pharmacol. 148, 619-628 (2006).

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