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GW 7647 (CAS 265129-71-3) LS-H23

PPAR alpha agonist
LS-H23-1 / 1 mg / $185
LS-H23-5 / 5 mg / $235
LS-H23-10 / 10 mg / $275
LS-H23-25 / 25 mg / $385
USA Shipment Only
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Description: Peroxisome proliferator-activated receptor- alpha (PPAR alpha) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPAR alpha results in expression of a variety of genes, particularly those involved in fatty acid beta -oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPAR alpha It activates human PPAR alpha, PPAR gamma, and PPAR delta with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg. H23_ChemicalStructureImage.png
2-methyl-2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-propanoic acid
biochemical, chemical, agonist
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PPARA / PPAR Alpha related products

Usage Information

GW 7647 is supplied as a crystalline solid. A stock solution may be made by dissolving the GW 7647 in an organic solvent purged with an inert gas. GW 7647 is soluble in an organic solvent, such as DMSO. The solubility of GW 7647 in DMSO is approximately 15 mg/ml.

  1. Latruffe, N. and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism Biochimie 79, 81-94 (1997).
  2. Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol. 12, 335-363 (1996).
  3. Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol. Life Sci. 61, 393-419 (2004).
  4. Brown, P.J., Stuart, L.W., Hurley, K.P., et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorganic & Medicinal Chemistry Letters 11, 1225-1227 (2001).

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