Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Description: The liver X receptors, LXR alpha and LXR beta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXR alpha and LXR beta, activating the human isoforms with EC50 values of 190 and 30 nM, respectively. It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism. GW 3965 also affects inflammation and pressor responses through LXR alpha and LXR beta .
It should be stable for at least two years. GW 3965 (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the GW 3965 (hydrochloride) in the solvent of choice. GW 3965 (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of GW 3965 (hydrochloride) in ethanol is approximately 2 mg/ml and approximately 20 mg/ml in DMSO and DMF. GW 3965 (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GW 3965 (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. GW 3965 (hydrochloride) has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
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