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GW 3965 (hydrochloride) (CAS 405911-17-3) LS-H67

LXR alpha agonist, LXR beta agonist
LS-H67-1 / 1 mg / $185
LS-H67-5 / 5 mg / $225
LS-H67-10 / 10 mg / $255
USA Shipment Only
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Description: The liver X receptors, LXR alpha and LXR beta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXR alpha and LXR beta, activating the human isoforms with EC50 values of 190 and 30 nM, respectively. It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism. GW 3965 also affects inflammation and pressor responses through LXR alpha and LXR beta . H67_ChemicalStructureImage.png
3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride
biochemical, chemical, agonist
C33H31ClF3NO3 • HCl
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: NR1H3 / LXR Alpha related products

Usage Information

It should be stable for at least two years. GW 3965 (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the GW 3965 (hydrochloride) in the solvent of choice. GW 3965 (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of GW 3965 (hydrochloride) in ethanol is approximately 2 mg/ml and approximately 20 mg/ml in DMSO and DMF. GW 3965 (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GW 3965 (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. GW 3965 (hydrochloride) has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Gabbi, C., Warner, M., and Gustafsson, J.-Ä. Biochem. Biophys. Res. Commun. (2013).
  2. Collins, J.L., Fivush, A.M., Watson, M.A., et al. J. Med. Chem. 45, 1963-1966 (2002).
  3. Joseph, S.B., McKilligin, E., Pei, L., et al. Proc. Natl. Acad. Sci. USA 99(11), 7604-7609 (2002).
  4. Hazra, S., Rasheed, A., Bhatwadekar, A., et al. Diabetes 61(12), 3270-3279 (2012).
  5. Joseph, S.B., Castrillo, A., Lafitte, B.A., et al. Nat. Med. 9(2), 213-219 (2003).
  6. Archer, A., Stolarczyk, É., Doria, M.L., et al. J. Lipid Res. 54(5), 1300-1311 (2013).

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