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Grifolic Acid (CAS 80557-12-6) LS-H137

GPR120 agonist
LS-H137-250 / 250 µg / $185
LS-H137-500 / 500 µg / $205
LS-H137-1000 / 1000 µg / $235
USA Shipment Only
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Description: GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long-chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin secretion. Grifolic acid is a selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously, but not those expressing GPR40. H137_ChemicalStructureImage.png
2,4-dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid
 
biochemical, chemical, agonist
LS-H137
80557-12-6
C23H32O4
≥95%
A crystalline solid
 
OC1=C(C/C=C(CC/C=C(C)/CC/C=C(C)\C)\C)C(O)=CC(C)=C1C(O)=O
InChI=1S/C23H32O4/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-19-20(24)14-18(5)21(22(19)25)23(26)27/h8,10,12,14,24-25H,6-7,9,11,13H2,1-5H3,(H,26,27)/b16-10+,17-12+
QPIZDZGIXDKCRC-JTCWOHKRSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: O3FAR1 / GPR120 related products

Usage Information

Grifolic acid is supplied as a crystalline solid. A stock solution may be made by dissolving the grifolic acid in the solvent of choice. Grifolic acid is soluble in organic solvents such as DMSO, which should be purged with an inert gas. The solubility of grifolic acid in this solvent is approximately 100 mg/ml.

References:
  1. Sun, Q., Hirasawa, A., Hara, T., et al. Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol. Pharm. 78, 804-810 (2010).

 


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