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Gamma-Linolenic Acid ethyl ester (CAS 31450-14-3) LS-H163

LTB4 receptor antagonist
LS-H163-50 / 50 mg / $175
LS-H163-100 / 100 mg / $195
LS-H163-250 / 250 mg / $235
USA Shipment Only
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Description: gamma -Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction. GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets. H163_ChemicalStructureImage.png
6Z,9Z,12Z-octadecatrienoic acid, ethyl ester
GLAethylester
biochemical, chemical, antagonist
LS-H163
31450-14-3
C20H34O2
≥98%
A solution in ethanol
0
CCCCC/C=C\C/C=C\C/C=C\CCCCC(OCC)=O
InChI=1S/C20H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22-4-2/h8-9,11-12,14-15H,3-7,10,13,16-19H2,1-2H3/b9-8-,12-11-,15-14-
MJLYTDAIYLGSRZ-ORZIMQNZSA-N
Shipped at 4°C, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Leukotriene B4 Receptor / BLT1 related products

Usage Information

GLA ethyl ester is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as DMSO and dimethyl formamide purged with an inert gas can be used. The solubility of GLA ethyl ester in these solvents is approximately 100 mg/ml. If aqueous stock solutions are required for biological experiments, they can best be prepared by diluting the organic solvent into aqueous buffers or isotonic saline. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot. Essent. Fatty Acids 52, 293-297 (1995).

 


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