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DL-AP5 (CAS 76326-31-3) LS-H99

NMDA receptor antagonist
LS-H99-5 / 5 mg / $185
LS-H99-10 / 10 mg / $195
LS-H99-25 / 25 mg / $255
LS-H99-50 / 50 mg / $335
USA Shipment Only
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Description: DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5 . Whereas D-AP5 is the active (-)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 µM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory. H99_ChemicalStructureImage.png
5-phosphono-norvaline
DL-2-Amino-5-Phosphonovalericacid
2-APV
biochemical, chemical, antagonist
LS-H99
76326-31-3
C5H12NO5P
≥95%
A crystalline solid
0
OP(CCCC(C(O)=O)N)(O)=O
InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
VOROEQBFPPIACJ-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: GRIN1 / NMDAR1 related products

Usage Information

DL-AP5 is supplied as a crystalline solid. A stock solution may be made by dissolving the DL-AP5 in the solvent of choice. DL-AP5 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of DL-AP5 in ethanol and DMSO is approximately 5 mg/ml and approximately 1 mg/ml in DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of DL-AP5 can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of DL-AP5 in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Evans, R.H., Francis, A.A., Jones, A.W., et al. The Effects of a Series of ω-Phosphonic a-Carboxylic Amino Acids on Electrically Evoked and Excitant Amino Acid-Induced Responses in Isolated Spinal Cord Preparations. Br. J. Pharmac. 75, 65-75 (1982).
  2. Morris, R.J. Synaptic Plasticity and Learning: Selective Impairment of Learning in Rats and Blockade of Long-Term Potentiation in vivo by the N-Methyl-D-Aspartate Receptor Antagonist AP5. J. Neurosci. 9, 3040-3057 (1989).

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