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Diethylstilbestrol (CAS 56-53-1) LS-H9

Estrogen receptor agonist
LS-H9-1000 / 1000 mg / $175
LS-H9-5000 / 5000 mg / $225
LS-H9-10000 / 10000 mg / $275
LS-H9-25000 / 25000 mg / $405
USA Shipment Only
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Description: Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring. DES is structurally related to, and is as potent as, estradiol in most assays, with a longer half-life. It has a relative binding affinity to sex hormone binding globulin (SHBG) of 0.2 compared to estradiol which has a relative binding affinity of 100. A concentration of 20 µM DES, displaces 30-13% of 3H-estradiol from SHBG in serum. H9_ChemicalStructureImage.png
4,4'[(1E)-1,2-diethyl-1,2-ethenediyl]bis-phenol
 
biochemical, chemical, agonist
LS-H9
56-53-1
C18H20O2
≥98%
A crystalline solid
 
CC\C(=C(\CC)/c1ccc(O)cc1)\c1ccc(O)cc1
InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
RGLYKWWBQGJZGM-ISLYRVAYSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: ER Alpha / Estrogen Receptor related products

Usage Information

DES is supplied as a crystalline solid. A stock solution may be made by dissolving the DES in an organic solvent purged with an inert gas. DES is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of DES in these solvents is approximately 30 mg/ml. DES is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, DES should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. DES has a solubility of approximately 0.15 mg/ml in a 1:5 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Coelingh Bennink, H.J.T. Are all estrogens the same? Maturitas 47, 269-275 (2003).
  2. Jury, H.H., Zaxharewski, T.R., and Hammond, G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J. Steroid Biochem. Molec. Biol. 75, 167-176 (2000).

 


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