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CYM 5541 (CAS 945128-26-7) LS-H114

S1P3 agonist
LS-H114-5 / 5 mg / $205
LS-H114-10 / 10 mg / $255
LS-H114-25 / 25 mg / $375
LS-H114-50 / 50 mg / $605
USA Shipment Only
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Description: The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). It less effectively activates S1P1 (EC50 = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters. H114_ChemicalStructureImage.png
N,N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
CID-17253208
ML-249
biochemical, chemical, agonist
LS-H114
945128-26-7
C19H28N2O2
≥98%
A crystalline solid
 
O=C(N(C1CCCCC1)C2CCCCC2)C3=NOC(C4CC4)=C3
InChI=1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
NDKGACIWVAOUQH-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: SIPR3 / EDG3 / S1P3 related products

Usage Information

CYM 5541 is supplied as a crystalline solid. A stock solution may be made by dissolving the CYM 5541 in the solvent of choice. CYM 5541 is soluble in DMSO at a concentration of approximately 5 mg/ml.

References:
  1. Choi, J.W., Lee, C.-W., and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochim. Biophys. Acta 1781, 531-539 (2008).
  2. Rosen, H., Stevens, R.C., Hanson, M., et al. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence. Annu. Rev. Biochem. 82, 637-662 (2013).
  3. Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., et al. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3), in Probe Reports from the NIH Molecular Libraries Program,1 (2011).
  4. Jo, E., Bhhatarai, B., Repetto, E., et al. Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem. Biol. 7(12), 1975-1983 (2012).

 


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