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Combrestatin A4 3'-O-Phosphate (sodium salt) (CAS 168555-66-6) LS-H12

Tubulin polymerization inhibitor
LS-H12-1 / 1 mg / $185
LS-H12-5 / 5 mg / $205
LS-H12-10 / 10 mg / $245
LS-H12-25 / 25 mg / $335
USA Shipment Only
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Description: Combretastatin A4 (CA4) is a potent inhibitor of tubulin polymerization that displays strong inhibitory activity on tumor cell growth. Combretastatin-A-4-3'-O-Phosphate (CA4P) is a CA4 prodrug that inhibits tumor growth in several cell lines including P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 ug/ml, respectively. CA4P specifically targets the tumor vasculature. In a rat model of carcinosarcoma, CA4P delivered intraperitoneally at a dose of 100 mg/kg effectively disrupts tumor blood flow within six hours after administration without significantly affecting normal tissues. H12_ChemicalStructureImage.png
2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol, dihydrogen phosphate, disodium salt
CA4P
CombrestatinA4
CRC87-09
biochemical, chemical, inhibitor
LS-H12
168555-66-6
C18H19O8P · 2Na
≥98%
A crystalline solid
0
COC(C(OP([O-])([O-])=O)=C1)=CC=C1/C=C\C2=CC(OC)=C(OC)C(OC)=C2
InChI=1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/p-2/b6-5-
WDOGQTQEKVLZIJ-WAYWQWQTSA-L
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Tubulin related products

Usage Information

CA4P (sodium salt) is sparingly soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. For biological experiments, we suggest that organic solvent-free aqueous solutions of CA4P (sodium salt) be prepared by directly dissolving the CA4P (sodium salt) compound in aqueous buffers. The solubility of CA4P (sodium salt) in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Pettie, G.R., Rhodes, M.R., Herald, D.L., et al. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A4. J. Med. Chem. 48, 4087-4099 (2005).
  2. Tozer, G.M., Prise, V.E., Wilson, J., et al. Combretastatin A4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues. Cancer Res. 59, 1626-1634 (1999).

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