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Clobenpropit (hydrobromide) (CAS 145231-35-2) LS-H54

Histamine H3 receptor antagonist
LS-H54-1 / 1 mg / $185
LS-H54-5 / 5 mg / $245
LS-H54-10 / 10 mg / $315
LS-H54-25 / 25 mg / $515
USA Shipment Only
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Description: Clobenpropit dihydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier; inhibits histamine binding in rat brain with an ED50 value of 10.5 mg/kg; protects cultured cortical neurons from NMDA-induced excitotoxicity by stimulating GABA release; in mice and rats protects against kindled seizures through its effects on histamine and GABA. H54_ChemicalStructureImage.png
N-[(4-chlorophenyl)methyl]-3-(1H-imidazol-5-yl)propyl ester, carbamimidothioic acid, dihydrobromide
CarbamimidothioicAcid
VUF-9153
biochemical, chemical, antagonist
LS-H54
145231-35-2
C14H17ClN4S · 2HBr
≥98%
A crystalline solid
 
N=C(SCCCc1cnc[nH]1)NCc1ccc(Cl)cc1
InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
UCAIEVHKDLMIFL-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: HRH3 / Histamine 3 Receptor related products

Usage Information

Clobenpropit (dihydrobromide) is supplied as a crystalline solid. A stock solution may be made by dissolving the clobenpropit (dihydrobromide) in an organic solvent purged with an inert gas. Clobenpropit (dihydrobromide) is soluble in organic solvents such as ethanol and DMSO. The solubility of clobenpropit (dihydrobromide) in ethanol and DMSO is approximately 2.5 and 30 mg/ml, respectively. Organic solvent-free aqueous solutions of clobenpropit (dihydrobromide) can be prepared by directly dissolving the crystalline compound in water. The solubility of clobenpropit (dihydrobromide) in water, is approximately 20 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Barnes, J.C., Brown, J.D., Clarke, N.P., et al. Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist. Eur. J. Pharmacol. 250, 147-152 (1993).
  2. Dai, H., Fu, Q., Shen, Y., et al. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur. J. Pharmacol. 563, 117-123 (2007).
  3. Harada, C., Fujii, Y., Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Res. Bull. 63, 143-146 (2004).

 


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