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CD1530 (CAS 107430-66-0) LS-H153

Retinoid X receptor agonist
LS-H153-1 / 1 mg / $185
LS-H153-5 / 5 mg / $235
LS-H153-10 / 10 mg / $265
USA Shipment Only
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Description: CD1530 is a selective retinoic acid receptor (RAR gamma) agonist (Kds = 150, 1,500, and 2,750 nM for RAR gamma, RAR beta, and RAR alpha receptors, respectively). It demonstrates transcriptional activity at RAR gamma with an AC50 value of 1.8 nM. It has been used in combination with bexarotene, a retinoid X receptor agonist, to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma. H153_ChemicalStructureImage.png
4-(6-hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)-benzoic acid
 
biochemical, chemical, agonist
LS-H153
107430-66-0
C27H26O3
≥98%
A crystalline solid
 
OC(C1=CC=C(C2=CC(C=C(C34C[C@H](C[C@@H](C5)C4)C[C@H]5C3)C(O)=C6)=C6C=C2)C=C1)=O
InChI=1S/C27H26O3/c28-25-12-22-6-5-21(19-1-3-20(4-2-19)26(29)30)10-23(22)11-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)/t16-,17+,18-,27?
VCQGNUWOMLYNNG-PSAKPEQJSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: RXTA / RXR-Alpha related products

Usage Information

CD1530 is supplied as a crystalline solid. A stock solution may be made by dissolving the CD1530 in the solvent of choice. CD1530 is soluble at 1 molar equivalent NaOH to 50 mM. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Bernard, B.A., Bernardon, J.-M., Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochem. Biophys. Res. Commun. 186(2), 977-983 (1992).
  2. Tang, X.-H., Osei-Sarfo, K., Urvalek, A.M., et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc. Natl. Acad. Sci. USA 111(24), 8907-8912 (2014). O HO OH PRODUCT INFORMATION

 


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