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Calcipotriol (hydrate) (CAS 112828-00-9) LS-H32

Vitamin D receptor agonist
LS-H32-10 / 10 mg / $195
LS-H32-50 / 50 mg / $335
LS-H32-100 / 100 mg / $475
LS-H32-500 / 500 mg / $2055
USA Shipment Only
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Description: Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes. H32_ChemicalStructureImage.png
24-cyclopropyl-(1α,3β,5Z,7E,22E,24S)-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, monohydrate
Calcipotriene
biochemical, chemical, agonist
LS-H32
112828-00-9
C27H40O3 · H2O
≥98%
A crystalline solid
 
C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2CCC[C@@]3(C)[C@@]\2([H])CC[C@]3([H])[C@H](C)/C=C/[C@@H](O)C4CC4.O
InChI=1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
XBKHACNRWFKJNC-MANNPBRJSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Vitamin D Receptor / VDR related products

Usage Information

Calcipotriol (hydrate) is supplied as a crystalline solid. A stock solution may be made by dissolving the calcipotriol (hydrate) in an organic solvent purged with an inert gas. Calcipotriol (hydrate) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of calcipotriol (hydrate) in these solvents is approximately 50 mg/ml. Calcipotriol (hydrate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Calcipotriol (hydrate) should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Calcipotriol (hydrate) has a solubility of approximately 0.15 mg/ml in a 1:5 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Kragballe, K. Vitamin D analogues in the treatment of psoriasis. J. Cell. Biochem. 49, 46-52 (1992).
  2. Johansen, C., Kragballe, K., Rasmussen, M., et al. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. Br. J. Dermatol. 151, 600-607 (2004).
  3. Li, M., Hener, P., Zhang, Z., et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc. Natl. Acad. Sci. USA 103(31), 11736-11741 (2006).

 


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