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Bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane (CAS 116673-45-1) LS-H160

PAF receptor antagonist
LS-H160-1 / 1 mg / $185
LS-H160-5 / 5 mg / $265
LS-H160-10 / 10 mg / $345
USA Shipment Only
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Description: trans-BTP Dioxolane is a PAF receptor antagonist. This compound demonstrates competitive antagonism of PAF in a rabbit washed platelet assay (Ki = 0.3 µM). H160_ChemicalStructureImage.png
trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
trans-BTPDioxolane
biochemical, chemical, antagonist
LS-H160
116673-45-1
C21H26O8
≥98%
A crystalline solid
0
COC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC
InChI=1S/C21H26O8/c1-22-14-7-12(8-15(23-2)19(14)26-5)18-11-28-21(29-18)13-9-16(24-3)20(27-6)17(10-13)25-4/h7-10,18,21H,11H2,1-6H3/t18-,21+/m0/s1
DUAYHYGJMLZLCE-GHTZIAJQSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PTAFR / PAF Receptor related products

Usage Information

trans-BTP dioxolane is supplied as a crystalline solid. A stock solution may be made by dissolving the trans-BTP dioxolane in an organic solvent purged with an inert gas. trans-BTP dioxolane is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of trans-BTP dioxolane in ethanol is approximately 35 mg/ml, but in DMSO and dimethyl formamide it is approximately 50 mg/ml. trans-BTP dioxolane will be stable for at least six months in these solvents if stored at -20°C. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. trans-BTP dioxolane is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, trans-BTP dioxolane should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. trans-BTP dioxolane has a solubility of approximately 2.5 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) and 100 μg/ml in a 1:10 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Corey, E.J., Chen, C.-P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Lett. 29, 2899-2902 (1988).

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