Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
trans-BTP dioxolane is supplied as a crystalline solid. A stock solution may be made by dissolving the trans-BTP dioxolane in an organic solvent purged with an inert gas. trans-BTP dioxolane is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of trans-BTP dioxolane in ethanol is approximately 35 mg/ml, but in DMSO and dimethyl formamide it is approximately 50 mg/ml. trans-BTP dioxolane will be stable for at least six months in these solvents if stored at -20°C. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. trans-BTP dioxolane is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, trans-BTP dioxolane should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. trans-BTP dioxolane has a solubility of approximately 2.5 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) and 100 μg/ml in a 1:10 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Corey, E.J., Chen, C.-P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Lett. 29, 2899-2902 (1988).