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BayCysLT2 (CAS 712313-33-2) LS-H69

CysLT2 receptor antagonist
LS-H69-1 / 1 mg / $195
LS-H69-5 / 5 mg / $295
LS-H69-10 / 10 mg / $405
LS-H69-25 / 25 mg / $785
USA Shipment Only
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Description: The cysteinyl leukotrienes LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G-protein coupled receptors, CysLT1 and CysLT2. BayCysLT2 is a potent CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and >10,000 nM, respectively. BayCysLT2 concentration-dependently reverses LTC4-stimulated perfusion pressure increase and contractility decrease in isolated Langendorff-perfused guinea pig hearts. H69_ChemicalStructureImage.png
3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-benzoic acid
CAY10633
biochemical, chemical, antagonist
LS-H69
712313-33-2
C34H39NO8
≥95%
A crystalline solid
0
O=C(NC1CCCC(C(O)=O)C1)C2=CC(C(O)=O)=CC=C2OCCCC(C=C3)=CC=C3OCCCCOC4=CC=CC=C4
InChI=1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)(H,37,38)(H,39,40)
GKPAULTWHHPIHX-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: CYSLT2 / CYSLTR2 related products

Usage Information

BayCysLT2 is supplied as a crystalline solid. A stock solution may be made by dissolving the BayCysLT2 in the solvent of choice. BayCysLT2 is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of BayCysLT2 in these solvents is approximately 20 mg/ml. BayCysLT2 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, BayCysLT2 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. BayCysLT2 has a solubility of approximately 0.1 mg/ml in a 1:9 solution of DMF:PBS (pH 7.2) using this method.We do not recommend storing the aqueous solution for more than one day.

References:
  1. Lynch, K.R., O’Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999).
  2. Heise, C.E., O’Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000).
  3. Sarau, H.M., Ames, R.S., Chambers, J., et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56, 657-663 (1999).
  4. Harter, M., Erguden, J., Wunder, F., et al. Isophtalic acid derivatives. US 2006/0154912 A1 (2006), 1-104, 10/537,623.

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