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ZM 336372 (CAS 208260-29-1) LS-H45

Raf-1 inhibitor
LS-H45-1 / 1 mg / $175
LS-H45-5 / 5 mg / $205
LS-H45-10 / 10 mg / $235
LS-H45-25 / 25 mg / $325
USA Shipment Only
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Description: The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation. H45_ChemicalStructureImage.png
3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
 
biochemical, chemical, inhibitor
LS-H45
208260-29-1
C23H23N3O3
>98%
A crystalline solid
 
Oc1ccc(cc1)C(=O)Nc1cc(ccc1C)NC(=O)c1cccc(c1)N(C)C
InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
PYEFPDQFAZNXLI-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: RAF1 / RAF related products

Usage Information

ZM 336372 is supplied as a crystalline solid. A stock solution may be made by dissolving the ZM 336372 in an organic solvent purged with an inert gas. ZM 336372 is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of ZM 336372 in these solvents is approximately 20 mg/ml. ZM 336372 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, ZM 336372 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. ZM 336372 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Hall-Jackson, C.A., Eyers, P.A., Cohen, P., et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chemistry & Biology 6, 559-568 (1999).
  2. Van Gompel, J.J., Kunnimalaiyaan, M., Holen, K., et al. ZM 336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol. Cancer Ther. 4(6), 910-917 (2005).

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