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WWL70 (CAS 947669-91-2) LS-H57

ABHD6 inhibitor
LS-H57-1 / 1 mg / $185
LS-H57-5 / 5 mg / $235
LS-H57-10 / 10 mg / $295
LS-H57-25 / 25 mg / $455
USA Shipment Only
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Description: Alpha / beta-Hydrolase domain-containing protein 6 (ABHD6) is a serine hydrolase that is highly expressed in mammalian brain. This enzyme catalyzes the hydrolysis of the endocannabinoid 2-arachidonoyl glycerol (2-AG). WWL70 is a selective inhibitor of ABHD6 with an IC50 value of 70 nM. H57_ChemicalStructureImage.png
N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-carbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
 
biochemical, chemical, inhibitor
LS-H57
947669-91-2
C27H23N3O3
≥97%
A crystalline solid
 
O=C(Oc1ccc(cc1)c1ccc(cc1)C(=O)N)N(C)Cc1cccc(c1)c1ccncc1
InChI=1S/C27H23N3O3/c1-30(18-19-3-2-4-24(17-19)22-13-15-29-16-14-22)27(32)33-25-11-9-21(10-12-25)20-5-7-23(8-6-20)26(28)31/h2-17H,18H2,1H3,(H2,28,31)
QTWNORFUQILKJL-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: ABHD6 related products

Usage Information

WWL70 is supplied as a crystalline solid. A stock solution may be made by dissolving the WWL70 in an organic solvent purged with an inert gas. WWL70 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF). The solubility of WWL70 in these solvents is approximately 1 mg/ml. WWL70 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, WWL70 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. WWL70 has a solubility of approximately 0.2 mg/mlin a 1:3 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Blankman, J.L., Simon, G.M., and Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology 14, 1347-1356 (2007).
  2. Li, W., Blankman, J.L., and Cravatt, B.F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. Journal of American Chemical Society 129, 9594-9595 (2007).

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