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Valdecoxib (CAS 181695-72-7) LS-H6

COX-2 inhibitor
LS-H6-5 / 5 mg / $205
LS-H6-25 / 25 mg / $335
LS-H6-50 / 50 mg / $485
USA Shipment Only
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Description: Valdecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits COX-2, exhibiting IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay. The COX-2 selectivity ratio of 30 for valdecoxib in this assay is similar to the ratio of 35 observed for rofecoxib . COX-2 selective inhibitors, including this compound, have been implicated as risk factors in acute atherothrombotic events. H6_ChemicalStructureImage.png
biochemical, chemical, inhibitor
A crystalline solid
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PTGS2 / COX2 / COX-2 related products

Usage Information

Valdecoxib is supplied as a crystalline solid. A stock solution may be made by dissolving the valdecoxib in an organic solvent purged with an inert gas. Valdecoxib is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of valdecoxib in these solvents is 5 mg/ml in ethanol and 20 mg/ml in DMSO and DMF. Valdecoxib is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, valdecoxib should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Valdecoxib has a solubility of 0.5 mg/ml in a 1:8 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Mardini, I.A. and Fitzgerald, G.A. Selective inhibitors of cyclooxygenase-2: A growing class of antiinflammatory drugs. Mol. Interv. 1, 30-38 (2001).
  2. Walter, M.F., Jacob, R.F., Day, C.A., et al. Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: Comparison to sulfonamide COX-2 inhibitors and NSAIDs. Atherosclerosis 177, 235-243 (2004).
  3. Zhang, J., Ding, E.L., and Song, Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: Meta-analysis of randomized trials. JAMA 296(13), 1619-1632 (2006).


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