Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Description: UDP-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14 receptor (EC50 = 0.35 µM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells. It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 µM.
P'-α-D-glucopyranosyl ester uridine 5'-(trihydrogen diphosphate), disodium salt
UDP-α-D-Glucose (UDPG) (sodium salt) is supplied as a crystalline solid. Aqueous solutions of (UDPG) (sodium salt) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of (UDPG) (sodium salt) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
Lecca, D., Trincavelli, M.L., Gelosa, P., et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 3(10), (2008).