LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

T0070907 (CAS 313516-66-4) LS-H65

PPAR gamma receptor agonist
LS-H65-1 / 1 mg / $165
LS-H65-5 / 5 mg / $185
LS-H65-10 / 10 mg / $215
LS-H65-50 / 50 mg / $385
USA Shipment Only
Order Button
100% Guaranteed 100% Guaranteed

Description: The peroxisome proliferator-activated receptor- gamma (PPAR gamma) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPAR gamma receptor agonists with antidiabetic actions in vivo. There are many PPAR gamma agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. T0070907 is a potent and selective antagonist of the human PPAR gamma with an apparent IC50 of 1 nM for the binding inhibition of rosiglitazone, a reference TZD. T0070907 covalently binds to Cys313 of PPAR gamma, inducing conformational changes that block the recruitment of transcriptional cofactors to the PPAR gamma /RXR heterodimer. H65_ChemicalStructureImage.png
2-chloro-5-nitro-N-4-pyridinyl-benzamide
 
biochemical, chemical, agonist
LS-H65
313516-66-4
C12H8ClN3O3
≥98%
A crystalline solid
 
ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O
InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
FRPJSHKMZHWJBE-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PPARG / PPAR Gamma related products

Usage Information

T0070907 is supplied as a crystalline solid. A stock solution may be made by dissolving the T0070907 in an organic solvent purged with an inert gas. T0070907 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF). The solubility of T0070907 in these solvents is approximately 10 mg/ml. T0070907 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, T0070907 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. T0070907 has a solubility of 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Willson, T.M., Cobb, J.E., Cowan, D.J., et al. J. Med. Chem. 39, 665-668 (1996).
  2. Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al. J. Med. Chem. 37, 3977-3985 (1994).
  3. Davies, S.S., Pontsler, A.V., Marathe, G.K., et al. J. Biol. Chem. 276, 16015-16023 (2001).
  4. Maxey, K.M., Hessler, E., MacDonald, J., et al. Prostaglandins and Other Lipid Mediators 62, 15-21 (2000).
  5. Wright, H.M., Clish, C.B., Mikami, T., et al. J. Biol. Chem. 275, 1873-1877 (2000).

 


Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2017 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number