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Sumatriptan (succinate) (CAS 103628-48-4) LS-H100

5-HT1 receptor agonist
LS-H100-5 / 5 mg / $175
LS-H100-10 / 10 mg / $195
LS-H100-25 / 25 mg / $235
LS-H100-50 / 50 mg / $295
USA Shipment Only
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Description: Sumatriptan (succinate) is a serotonin 5-hydroxytryptamine 1 (5-HT1) receptor agonist with selective affinity for 5-HT1B and 5-HT1D receptors with IC50 values of 9.3 and 7.3 nM, respectively. It also has affinity for the 5-HT1F receptor (IC50 = 17.8 nM). Sumatriptan (succinate) has been shown to induce vasoconstriction of human middle meningeal arteries (EC50 = 89.9 nM) and reduce vascular inflammation associated with migraines. H100_ChemicalStructureImage.png
3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide-butanedioic acid
GR43175C
Imigran
Imitrex
biochemical, chemical, agonist
LS-H100
103628-48-4
C14H21N3O2S • C4H6O4
≥98%
A crystalline solid
0
CN(C)CCC1=CNC2=CC=C(CS(NC)(=O)=O)C=C21.O=C(CCC(O)=O)O
InChI=1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
PORMUFZNYQJOEI-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: HTR1A / 5-HT1A Receptor related products

Usage Information

Sumatriptan (succinate) is supplied as a crystalline solid. A stock solution may be made by dissolving the sumatriptan (succinate) in the solvent of choice. Sumatriptan (succinate) is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of sumatriptan (succinate) in these solvents is approximately 30 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of sumatriptan (succinate) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of sumatriptan (succinate) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Razzaque, Z., Heald, M.A., Pickard, J.D., et al. Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br. J. Clin. Pharmacol. 47(1), 75-82 (1999).

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