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Raclopride (CAS 84225-95-6) LS-H138

Dopamine D2 receptor antagonist
LS-H138-5 / 5 mg / $185
LS-H138-10 / 10 mg / $195
LS-H138-25 / 25 mg / $245
LS-H138-50 / 50 mg / $305
USA Shipment Only
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Description: Raclopride is a selective dopamine D2/D3 receptor antagonist with Ki values of 1.8, 3.5, 2,400, and 18,000 nM for D2, D3, D4, and D1 receptors, respectively. It passes the blood brain barrier and can be used in in vivo binding and autoradiography studies of the dopamine system under normal and pathological conditions such as Huntington's disease. H138_ChemicalStructureImage.png
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxy-benzamide
(S)-(-)-Raclopride
biochemical, chemical, antagonist
LS-H138
84225-95-6
C15H20Cl2N2O3
≥99%
A solid
0
OC1=C(Cl)C=C(Cl)C(OC)=C1C(NC[C@@H]2CCCN2CC)=O
InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
WAOQONBSWFLFPE-VIFPVBQESA-N
Shipped Ambient, store Ambient, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: DRD2 / Dopamine Receptor D2 related products

Usage Information

Raclopride is supplied as a solid. A stock solution may be made by dissolving the raclopride in the solvent of choice. Raclopride is soluble in organic solvents such as ethanol and DMSO, which should be purged with an inert gas. The solubility of raclopride in these solvents is approximately up to 20 and 100 mM, resepectively.

References:
  1. Seeman, P., and Van Tol, H.H.M. Dopamine receptor pharmacology. Trends. Pharmacol. Sci. 15(7), 264-270 (1994).
  2. Lidow, M.S., Goldman-Rakic, P.S., Rakic, P., et al. Dopamine D2 receptors in the cerebral cortex: Distribution and pharmacological characterization with [3H]raclopride. Proc. Natl. Acad. Sci. USA 86, 6412-6416 (1989).
  3. Ginovart, N. Imaging the dopamine system with in vivo [11C]raclopride displacement studies: Understanding the true mechanism. Mol. Imaging Biol. 7, 45-52 (2005).

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