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Philanthotoxin 74 (hydrochloride) (CAS 1227301-51-0) LS-H101

AMPA receptor antagonist
LS-H101-1 / 1 mg / $195
LS-H101-10 / 10 mg / $235
USA Shipment Only
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Description: Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM. PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM. H101_ChemicalStructureImage.png
N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-αS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride
biochemical, chemical, antagonist
C24H42N4O3 • 2HCl
A white to off white solid
Shipped Ambient, store Ambient, ≥ 6 months shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: GRIA1 / GLUR1 related products

Usage Information

PhTx-74 (hydrochloride) is supplied as a white to off-white solid. A stock solution may be made by dissolving the PhTx-74 (hydrochloride) in the solvent of choice. PhTx-74 (hydrochloride) is soluble in the organic solvent DMSO. It is also soluble in water. The solubility of PhTx-74 (hydrochloride) in DMSO and water is approximately 100 mM. We do not recommend storing the aqueous solution for more than one day.

  1. Nilsen, A. and England, P.M. A subtype-selective, use-dependent inhibitor of native AMPA receptors. J. Am. Chem. Soc. 129(16), 4902-4903 (2007).
  2. Kromann, H., Krikstolaityte, S., Andersen, A.J., et al. Solid-phase synthesis of polyamine toxin analogues: Potent and selective antagonists of Ca2+-permeable AMPA receptors. J. Med. Chem. 45(26), 5745-5754 (2002).

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