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PF-750 (CAS 959151-50-9) LS-H52

FAAH inhibitor
LS-H52-1 / 1 mg / $165
LS-H52-5 / 5 mg / $205
LS-H52-10 / 10 mg / $235
LS-H52-50 / 50 mg / $475
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Description: Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.6 and 0.016 µM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 µM. H52_ChemicalStructureImage.png
biochemical, chemical, inhibitor
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FAAH related products

Usage Information

PF-750 is supplied as a crystalline solid. A stock solution may be made by dissolving the PF-750 in an organic solvent purged with an inert gas. PF-750 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of PF-750 in ethanol is approximately 1 mg/ml and approximately 20 mg/ml in DMSO and DMF. PF-750 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, PF-750 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. PF-750 has a solubility of approximately 0.125 mg/ml in a 1:5 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Ahn, K., Johnson, D.S., Fitzgerald, L.R., et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46, 13019-13030 (2007).


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