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PF-622 (CAS 898235-65-9) LS-H51

FAAH inhibitor
LS-H51-1 / 1 mg / $175
LS-H51-5 / 5 mg / $225
LS-H51-10 / 10 mg / $265
LS-H51-50 / 50 mg / $695
USA Shipment Only
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Description: Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-622 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.99 and 0.033 µM when preincubated with human recombinant FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-622 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 µM. H51_ChemicalStructureImage.png
biochemical, chemical, inhibitor
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FAAH related products

Usage Information

PF-622 is supplied as a crystalline solid. A stock solution may be made by dissolving the PF-622 in an organic solvent purged with an inert gas. PF-622 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of PF-622 in these solvents are approximately 0.3, 2, and 3 mg/ml, respectively. PF-622 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, PF-622 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. PF-622 has a solubility of approximately 0.15 mg/ml in a 1:5 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Ahn, K., Johnson, D.S., Fitzgerald, L.R., et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46, 13019-13030 (2007).

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