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Montelukast (sodium salt) (CAS 151767-02-1) LS-H17

CysLT1 receptor antagonist
LS-H17-10 / 10 mg / $175
LS-H17-50 / 50 mg / $205
LS-H17-100 / 100 mg / $235
LS-H17-500 / 500 mg / $515
USA Shipment Only
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Description: The cysteinyl leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2. Montelukast (sodium salt) is a potent, selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist sold under the trade name Singulair for the treatment of asthma as well as for the symptoms associated with allergic rhinitis. It binds to the human CysLT1 receptor with an IC50 of less than 5 nM with no appreciable binding to the CysLT2 receptor. H17_ChemicalStructureImage.png
1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt
Singulair®
biochemical, chemical, antagonist
LS-H17
151767-02-1
C35H35ClNO3S • Na
≥98%
A crystalline solid
 
CC(C)(O)C(C=CC=C1)=C1CC[C@@H](SCC2(CC2)CC([O-])=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.[Na+]
InChI=1S/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);/q;+1/p-1/b15-10+;/t32-;/m1./s1
LBFBRXGCXUHRJY-HKHDRNBDSA-M
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: CYSLTR1 / CYSLT1 related products

Usage Information

Montelukast (sodium salt) is supplied as a crystalline solid. A stock solution may be made by dissolving the montelukast (sodium salt) in the solvent of choice. Montelukast (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of montelukast (sodium salt) in these solvents is approximately 30 mg/ml. It is also soluble in water at a concentration of 10 mg/ml. Montelukast (sodium salt) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, montelukast (sodium salt) should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Montelukast (sodium salt) has a solubility of approximately 0.15 mg/ml in a 1:9 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Lynch, K.R., O’Neill, G.P., Liu, Q., et al. Nature 399, 789-793 (1999).
  2. Heise, C.E., O’Dowd, B.F., Figuerosa, D.J., et al. J. Biol. Chem. 275, 30531-30536 (2000).
  3. Sarau, H.M., Ames, R.S., Chambers, J., et al. Mol. Pharmacol. 56, 657-663 (1999).
  4. Leff, J.A., Busse, W.W., Pearlman, D., et al. N. Engl. J. Med. 339, 147-152 (1998).
  5. Reiss, T.F., Chervinsky, P., Dockhorn, R.J., et al. Arch. Intern. Med. 158, 1213-1220 (1998).
  6. Peters-Golden, M. and Henderson, W.R. Ann. Allergy Asthma Immunol. 94, 609-618 (2005).

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