• Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question?
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Contact Us

2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products. - To submit a new order. - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues. - To request technical information requests about an LSBio product or its application. - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

JNJ-7777120 (CAS 459168-41-3) LS-H62

Histamin H4 receptor antagonist
LS-H62-1 / 1 mg / $175
LS-H62-5 / 5 mg / $205
LS-H62-10 / 10 mg / $245
LS-H62-50 / 50 mg / $545
USA Shipment Only
Order Button
100% Guaranteed 100% Guaranteed

Description: JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors. Its Ki values for the histamine H1-3 receptors exceed 1 µM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters. JNJ-777120 inhibits mast cell chemotaxis induced by 10 µM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.). It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation. H62_ChemicalStructureImage.png
biochemical, chemical, antagonist
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: HRH4 / Histamine H4 Receptor related products

Usage Information

JNJ-7777120 is supplied as a crystalline solid. A stock solution may be made by dissolving the JNJ-7777120 in the solvent of choice. JNJ-7777120 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of JNJ-7777120 in these solvents is approximately 2 mg/ml in ethanol and approximately 14 mg/ml in DMSO and DMF. JNJ-7777120 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, JNJ-7777120 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. JNJ-7777120 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Thurmond, R.L., Desai, P.J., Dunford, P.J., et al. A potent and selective histamine H4 receptor antagonist with antiinflammatory properties. J. Pharmacol. Exp. Ther. 309(1), 404-413 (2004).
  2. Dunford, P.J., O’Donnell, N., Riley, J.P., et al. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J. Immunol. 176, 7062-7070 (2006).
  3. Cowden, J.M., Riley, J.P., Ma, J.Y., et al. Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines. Respir. Res. 11(86), (2010).

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2017 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number