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H2L5186303 (CAS 139262-76-3) LS-H103

LPA2 receptor antagonist
LS-H103-500 / 500 µg / $175
LS-H103-1000 / 1000 µg / $185
LS-H103-5000 / 5000 µg / $215
LS-H103-10000 / 10000 µg / $255
USA Shipment Only
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Description: H2L5186303 is a selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 9 nM in a LPA-elicited calcium mobilization assay). It inhibits LPA1 and LPA3 at much higher concentrations (IC50s = 27,354 and 4,504 nM, respectively). H103_ChemicalStructureImage.png
(Z,Z)-4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
 
biochemical, chemical, antagonist
LS-H103
139262-76-3
C26H20N2O8
≥98%
A crystalline solid
 
O=C(/C=C\C(O)=O)NC(C=C1)=CC=C1OC2=CC(OC3=CC=C(NC(/C=C\C(O)=O)=O)C=C3)=CC=C2
InChI=1S/C26H20N2O8/c29-23(12-14-25(31)32)27-17-4-8-19(9-5-17)35-21-2-1-3-22(16-21)36-20-10-6-18(7-11-20)28-24(30)13-15-26(33)34/h1-16H,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/b14-12-,15-13-
HZFPOTBCYPWQSH-DZDAAMPGSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: LPAR2 / EDG4 related products

Usage Information

H2L5186303 is supplied as a crystalline solid. A stock solution may be made by dissolving the H2L5186303 in the solvent of choice. H2L5186303 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of H2L5186303 in these solvents is approximately 15 and 20 mg/ml, respectively. H2L5186303 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, H2L5186303 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. H2L5186303 has a solubility of approximately 0.11 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Fells, J. I., Tsukahara, R., Liu, J., et al. Structure-based drug design identifies novel LPA3 antagonists. Bioorg. Med. Chem. 17(21), 7457-7464 (2009).

 


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