Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Description: Peroxisome proliferator-activated receptor delta (PPAR delta) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW 501516 is the first highly selective synthetic PPAR delta agonist available. GW 501516 binds to human PPAR delta with an IC50 value of 1 nM, and is at least 100-fold selective for PPAR delta compared to PPAR alpha and PPAR gamma . In obese primates, GW 501516 increases high density lipoprotein cholesterol and apolipoprotein A-1 specific reverse cholesterol transport. GW 501516 is therefore a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism.
GW 501516 is supplied as a crystalline solid. A stock solution may be made by dissolving the GW 501516 in an organic solvent purged with an inert gas. GW 501516 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of GW 501516 in these solvents is approximately 12, 20, and 25 mg/ml, respectively. GW 501516 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GW 501516 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. GW 501516 has a solubility of approximately 0.5 mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.