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GSA 10 (CAS 300833-95-8) LS-H123

SMO agonist
LS-H123-5 / 5 mg / $225
LS-H123-10 / 10 mg / $275
LS-H123-50 / 50 mg / $710
USA Shipment Only
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Description: Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site. H123_ChemicalStructureImage.png
4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester
 
biochemical, chemical, agonist
LS-H123
300833-95-8
C26H30N2O5
≥95%
A crystalline solid
 
O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(C=CC=C3)N(CCCCCC)C2=O)=O)C=C1
InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
MDLUYYGRCGDKGL-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: SMO / Smoothened related products

Usage Information

GSA 10 is supplied as a crystalline solid. A stock solution may be made by dissolving the GSA 10 in the solvent of choice. GSA 10 is soluble in dimethyl formamide at a concentration of approximately 1 mg/ml. GSA 10 is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Ruiz-Gómez, A., Molnar, C., Holguín, H., et al. The cell biology of Smo signalling and its relationships with GPCRs. Biochim. Biophys. Acta 1768(4), 901-912 (2007).
  2. Gorojankina, T., Hoch, L., Faure, H., et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol. Pharmacol. 83(5), 1020-1029 (2013).

 


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