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GPR120 Compound A (CAS 1599477-75-4) LS-H129

GPR120 agonist
LS-H129-1 / 1 mg / $175
LS-H129-5 / 5 mg / $235
LS-H129-10 / 10 mg / $305
LS-H129-50 / 50 mg / $650
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Description: GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin secretion. GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µM) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). This compound exerts anti-inflammatory effects on macrophages in vitro and improves glucose tolerance, decreases hyperinsulinemia, increases insulin sensitivity, and decreases hepatic steatosis when included at 30 mg/kg body weight in a high-fat diet fed to obese mice. H129_ChemicalStructureImage.png
3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid
biochemical, chemical, agonist
A crystalline solid
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: O3FAR1 / GPR120 related products

Usage Information

GPR120 compound A is supplied as a crystalline solid. A stock solution may be made by dissolving the GPR120 compound A in the solvent of choice. GPR120 compound A is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of GPR120 compound A in these solvents is approximately 30 mg/ml. GPR120 compound A is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GPR120 compound A should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. GPR120 compound A has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Oh da, Y., Walenta, E., Akiyama, T.E., et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat. Med. 20(8), 942-947 (2014).


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