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DC260126 (CAS 346692-04-4) LS-H155

GPR40 antagonist
LS-H155-1 / 1 mg / $175
LS-H155-5 / 5 mg / $195
LS-H155-10 / 10 mg / $215
LS-H155-25 / 25 mg / $265
USA Shipment Only
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Description: DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic beta -cell apoptosis in obese diabetic db/db mice. H155_ChemicalStructureImage.png
biochemical, chemical, antagonist
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FFAR1 / GPR40 related products

Usage Information

DC260126 is supplied as a crystalline solid. A stock solution may be made by dissolving the DC260126 in the solvent of choice. DC260126 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of DC260126 in these solvents is approximately 100, 20, and 30 mg/ml, respectively. DC260126 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, DC260126 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. DC260126 has a solubility of approximately 0.25 mg/ml in a 1:3 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Hu, H., He, L., Gong, Z., et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem. Bioph. Res. Commun. 390(3), 557-563 (2009).
  2. Sun, T., Wang, T., Zhou, Y., et al. DC260126: A small-molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice. PLoS One 8(6), (2013). 


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