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Commendamide (CAS 193825-78-4) LS-H150

GPR132 agonist
LS-H150-500 / 500 µg / $185
LS-H150-1000 / 1000 µg / $195
LS-H150-5000 / 5000 µg / $325
LS-H150-10000 / 10000 µg / $445
USA Shipment Only
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Description: Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 µM. H150_ChemicalStructureImage.png
N-(3-hydroxy-1-oxohexadecyl)-glycine
N-acyl-3-hydroxypalmitoyl-Glycine
biochemical, chemical, agonist
LS-H150
193825-78-4
C18H35NO4
≥95%
A crystalline solid
0
O=C(O)CNC(CC(O)CCCCCCCCCCCCC)=O
InChI=1S/C18H35NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(20)14-17(21)19-15-18(22)23/h16,20H,2-15H2,1H3,(H,19,21)(H,22,23)
MZUHHHSFDVDBCZ-UHFFFAOYSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: GPR132 / G2A related products

Usage Information

Commendamide is supplied as a crystalline solid. A stock solution may be made by dissolving the commendamide in the solvent of choice. Commendamide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of commendamide in these solvents is approximately 15, 20, and 25 mg/ml, respectively. Commendamide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, commendamide should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Commendamide has a solubility of approximately 0.3 mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Cohen, L.J., Kang, H.-S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc. Natl. Acad. Sci. USA 112(35), E4825-E4834 (2015).

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