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Combrestatin A4 (CAS 117048-59-6) LS-H11

Tubulin polymerization inhibitor
LS-H11-5 / 5 mg / $195
LS-H11-10 / 10 mg / $225
LS-H11-25 / 25 mg / $315
LS-H11-50 / 50 mg / $445
USA Shipment Only
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Description: Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 µM. H11_ChemicalStructureImage.png
2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol
CA4
CombretastatinA4
CRC87-09
biochemical, chemical, inhibitor
LS-H11
117048-59-6
C18H20O5
≥98%
A crystalline solid
 
COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1OC
InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
HVXBOLULGPECHP-WAYWQWQTSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Tubulin related products

Usage Information

CA4 is supplied as a crystalline solid. A stock solution may be made by dissolving the CA4 in an organic solvent purged with an inert gas. CA4 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of CA4 in DMSO is approximately 10 mg/ml and approximately 20 mg/ml in ethanol and DMF. CA4 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, CA4 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. CA4 has a solubility of approximately 0.1 mg/ml in a 1:10 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res. 24, 179-186 (2004).
  2. Dey, P. Chromatin remodeling, cancer and chemotherapy. Current Medicinal Chemistry 13, 2909-2919 (2006).

 


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