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Adenosine 5'-(γ-thio)-triphosphate (lithium salt) (CAS 93839-89-5) LS-H109

P2Y2 receptor agonist, P2Y11 agonist
LS-H109-1 / 1 mg / $175
LS-H109-5 / 5 mg / $215
LS-H109-10 / 10 mg / $265
USA Shipment Only
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Description: Adenosine 5'-(γ-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs, and can serve as a substrate for the RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A. H109_ChemicalStructureImage.png
P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt
ATPγS
biochemical, chemical, agonist
LS-H109
93839-89-5
C10H16N5O12P3S • 4Li
≥90%
A crystalline solid
 
O=P(OP(OP(O)(O)=S)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1.[Li].[Li].[Li].[Li]
InChI=1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/t4-,6-,7-,10-;;;;/m1..../s1
YADAOCUJWNGDQW-KWIZKVQNSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: P2RY2 / P2Y2 related products

Usage Information

ATPγS (lithium salt) is supplied as a crystalline solid. The solubility of ATPγS (lithium salt) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
  2. Knowles, J.R. Enzyme-catalyzed phosphoryl transfer reactions. Annu. Rev. Biochem. 49, 877-919 (1980).
  3. Chrysogelos, S., Register, J.C.I., and Griffith, J. The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5’-O-(3-thiotriphosphate). J. Biol. Chem. 258(20), 12624-12631 (1983).
  4. Peck, M.L. and Herschlag, D. Adenosine 5’-O-(3-thio)triphosphate (ATPγS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9(10), 1180-1187 (2003).

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